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& Lombard, D

The content of melanin in melanocytes was increased by maclurin in a dose-dependent manner, by a mechanism involving the activation of the cAMP/PKA/CREB signaling pathway, which in turn increased tyrosinase, MITF and their downstream TRP-1 and Trp-2 protein content, while also involving the activation of p38 MAPK and p44/42 MAPK pathways

(106) showed that 48 h fasting after prolonged MEL administration significantly altered changes in carbohydrate and lipid metabolism in young rats, and Markova et al

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Holmes, R